FIT test

Hi all, I have just sent off my FIT test, standard at my age. I was wondering because I have seen people mention calprotectin if anyone could help with a couple of questions?

I have occult blood and transferrin (digested blood from higher up) on a test, if the calprotectin level is normal does it mean no colon or small bowel cancer. 

If they find blood in the sample and low/ normal calprotectin does it mean you don't have to have a colonoscopy. ?

Thank you for any help

Sarah x

  • Hello and thanks for posting,

    Calprotectin is a test to estimate any inflammation in the bowel. It can be useful when other bowel diseases, including inflammatory bowel disease for example, is suspected. It is a useful test to distinguish between irritable bowel disease (non inflammatory), and inflammatory bowel disease, such as ulcerative colitis.

    So, calprotectin is not used as a standard marker test for bowel cancer, it is the FIT test that provides a level as part of bowel cancer population screening. There are certain criteria for referring people for a colonoscopy after these results. This will depend on the results of either or both tests, the clinical symptoms reported, and the need then for an urgent or non urgent referral for colonoscopy.

    I hope that this helps,

    Best wishes,

    Vanda

  • Thank you for your help Vanda. My sample was returned this week so hoping it got there, didn't realise there were postal strikes, but as the bottle is dated they will know if it has arrived too late and I guess send out a new test. I had a negative calprotectin test after a gastro consultant requested it because I had uptake in the ileum on a MIBG scan and she wanted to rule out inflammatory disorders. They were or are looking for a NET

    Best wishes Sarah